Details
Use: SAM-e is commonly used for many mind-body benefits, but we particularly like it to support a healthy mood
Directions: Take one capsule daily, or as directed by your healthcare practitioner.
Product Information: 30 count. All Resilient Remedies formulas meet or exceed cGMP quality standards.
Storage: Keep closed in a cool, dry place out of reach of children.
Does Not Contain: Wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.
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More about Uplifted Mood
Discussion
S-adenosyl-L-methionine (SAMe) is a naturally occurring substance formed in the body from the amino acid methionine and the “energy molecule” adenosine triphosphate (ATP). Formation of SAMe is catalyzed by methionine adenosyltransferase and depends on cofactors including vitamin B6, vitamin B12, folate, and magnesium. SAMe has been studied as a supportive nutrient in liver health, joint comfort, metabolic reactions, and healthy mood.*[1-4]
Clinical Applications
» Supports Biochemical Reactions Requiring Methyl Groups
» Supports Neurotransmitter Synthesis and Healthy Mood
» Facilitates Conversion of Homocysteine to Glutathione
» Supports Liver Health and Function
» Promotes Joint Comfort*
Methylation
SAMe is the “universal” methyl donor for biochemical reactions throughout the body.[5] This methyl transfer, or “transmethylation,” is critical to reactions involving proteins, phospholipids, DNA, RNA, creatine, hormones, development of
cell membranes, degradation of histamine, and formation of norepinephrine and dopamine. [1,6] Eighty-five percent of transmethylation takes place in the liver, and healthy SAMe levels appear to be essential to liver health and function.*[2,7]
Antioxidant and Liver Support
SAMe is considered to be “critical” for synthesis of glutathione, a principal component of antioxidant and detoxification systems inthe body.[1] Following donation of a methyl group, SAMe is converted to S-adenosyl- homocysteine (SAH). This biochemical reaction promotes the transsulfuration pathway in the liver that generates glutathione. Further metabolism of SAH involves trimethylglycine (TMG), also known as betaine anhydrous. TMG plays an important role in maintaining a healthy SAMe:SAH ratio in the liver.*
During a national symposium, the roles of SAMe and TMG in supporting liver health were reviewed with a focus on their participation in the vital processes of transmethylation and transsulfuration, their ultimate contribution to increased glutathione synthesis and its hepatoprotective effects, their promotion of a balanced SAMe:SAH ratio, their activation of phosphatidylethanolamine methyltransferase, and the increase in phosphatidylcholine synthesis as a result of their administration.[8] Ongoing animal studies suggest that SAMe supports liver health[9,10] and that exogenous SAMe may positively affect cell-life regulation of hepatocytes.[7] In certain human cohorts, researchers recommend further research into combining SAMe with nutrients such as vitamin B6 to optimize outcomes.*[5]
Healthy Mood
Supplemental SAMe appears to support a healthy mood, possibly due to its active role in methylation and its involvement in the formation of monoamine neurotransmitters.[3,11-13] Meta-analysis of earlier studies suggested that SAMe showed greater support of a healthy mood when compared to placebo with an effect comparable to that of other treatments.[14] A 30-day, double-blind, placebo-controlled, randomized study of 80 women suggested that there was a significant improvement in mood after the women received an oral dose of 1600 mg/d of SAMe compared to placebo.[15] Another study of 143 subjects who received an oral dose of 1600 mg/d of SAMe suggested that SAMe yielded positive results that were comparable to other treatments for supporting a healthy mood, but SAMe was better tolerated.[16] In a small (N=26), four-week, double-blind, randomized protocol comparing oral SAMe with other treatments, 62% of the SAMe group showed significant improvement in mood. The study revealed a significant correlation between plasma SAMe levels and the degree of healthy mood support, regardless of treatment type.*[17]
SAM-e
SAM-e contains a minimum of 70% of the SS isomer of SAMe, the form the body can use most readily. This relatively high concentration from Gnosis’ Adomix® not only makes SAM-e particularly bioavailable but also cost-effective. Each capsule is sealed in a nitrogen-purged blister pack to maximize protection from the environment.*
Before starting any supplement regimen, please download and discuss the information in this guide with your primary care physician. View/Download our Product Knowledge Guide.
Disclaimer
*The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from health care practitioners. Please consult your health care professional about potential interactions or other possible complications before using any product. The Federal Food, Drug, and Cosmetic Act require this notice. Do not use if tamper seal is damaged.